The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis
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چکیده
منابع مشابه
The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis
We recently found that integrin αvβ3 binds to fibroblast growth factor (FGF)-αvβ31 (FGF1), and that the integrin-binding defective FGF1 mutant (Arg-50 to glutamic acid, R50E) is defective in signalling and antagonistic to FGF1 signalling. R50E suppressed angiogenesis and tumour growth, suggesting that R50E has potential as a therapeutic. However, FGF1 is unstable, and we had to express R50E in ...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2017
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20170173